If you’re considering injectable treatments to smooth wrinkles and fine lines, you’ve probably heard of Botox. But have you heard of Xeomin?
Both are popular neurotoxin treatments that can help you achieve a more youthful, refreshed appearance, but they’re not exactly the same.
At DermaBlue, we often get questions about the differences between these two treatments. The good news is that both can be excellent options – the “best” choice really depends on your individual needs, skin type, and treatment goals. Let’s break down everything you need to know about Xeomin vs. Botox to help you make a more informed decision.
What Are Neurotoxin Injectables?
Before diving into the specifics, it’s helpful to understand what both Xeomin and Botox actually are.
Both belong to a class of treatments called neurotoxin injectables (hence the “tox” in Botox), which work by temporarily blocking nerve signals to specific facial muscles.
When these muscles can’t contract as strongly or as regularly, the skin above them appears smoother, reducing the appearance of wrinkles and fine lines.
Think of it this way: many of the wrinkles we develop over time (especially around the eyes, forehead, and between the brow) are caused by repeated muscle movements. Every time you squint, frown, or raise your eyebrows, you’re creating small creases in your skin. Over the years, these temporary creases become permanent lines.
Neurotoxin treatments essentially give those overactive muscles a break, allowing your skin to smooth out and preventing new lines from forming for the time being.
Meet Botox, The Most Popular Option
Botox (onabotulinumtoxinA) has been the gold standard in aesthetic neurotoxin treatments for decades. It was first FDA-approved for cosmetic use in 2002, making it the longest-established option in this category.
Most people are familiar with Botox, as it’s become virtually synonymous with wrinkle reduction treatments.
Botox is derived from botulinum toxin type A, the same active ingredient found in Xeomin.
What makes Botox unique?
It also contains additional proteins alongside the active neurotoxin. These proteins help stabilize the product and have contributed to its long track record of safety and effectiveness.
The treatment involves a series of small injections directly into the targeted muscles in the face. Most people describe the sensation as similar to a small pinprick—uncomfortable for a moment, but very manageable.
The entire appointment typically takes 15-20 minutes, making it easy to fit into a lunch break.
Xeomin: The “Pure” Alternative
Xeomin (incobotulinumtoxinA) is a newer player in the aesthetic world, having received FDA approval for cosmetic use in 2011.
What sets Xeomin apart?
Its “pure” formulation. It contains only the active neurotoxin without any additional proteins.
This difference might seem small, but it’s actually quite significant. Because Xeomin doesn’t contain accessory proteins, some practitioners refer to it as “naked botulinum toxin.” This purity means that your body is less likely to develop antibodies against the treatment, which can sometimes happen with repeated use of protein-containing neurotoxins.
Just like Botox, Xeomin is injected directly into the target muscles using a very fine needle. The treatment process is virtually identical, and most patients can’t tell the difference in terms of comfort level or procedure time.
How Do They Work? The Science Made Simple
Both Xeomin and Botox work through the same basic mechanism. When injected into a muscle, the neurotoxin blocks the release of acetylcholine, a chemical messenger that tells muscles to contract. Without this signal, the muscle relaxes, and the overlying skin appears smoother.
The key difference lies in how quickly your body processes each product. Because Xeomin is a “purer” formulation, some research suggests it may have a slightly faster onset in some patients. However, both products typically begin showing results within 3-7 days, with full effects visible within two weeks.
The duration of results is similar for both treatments – typically lasting 3-4 months, though this can vary based on factors like your metabolism, the strength of your facial muscles, and the area being treated.
Do They Work Equally Well?
Clinical studies have shown that both Xeomin and Botox are highly effective for treating dynamic wrinkles caused by muscle movement. Both products excel at treating:
- Frown lines between the eyebrows (glabellar lines)
- Crow’s feet around the eyes
- Horizontal forehead lines
- Lip lines and gummy smiles
- Neck bands
In head-to-head studies, both products have demonstrated comparable effectiveness. The choice between them often comes down to individual factors rather than a significant difference in how well they work.
That said, some patients do report preferring one over the other. This might be due to subtle differences in how the products spread once injected, individual body chemistry, or simply personal preference based on their experience.
Botox vs Xeomin Safety Differences
Both Xeomin and Botox have excellent safety profiles when administered by qualified professionals. The most common side effects are mild and temporary, including:
- Slight bruising or swelling at injection sites
- Temporary headache
- Mild drooping of the eyelid or eyebrow (rare and temporary)
Xeomin Safety
One potential advantage of Xeomin is its reduced likelihood of causing antibody formation. Some patients who receive neurotoxin treatments repeatedly over many years may develop antibodies that make the treatment less effective. Because Xeomin contains fewer foreign proteins, this resistance is theoretically less likely to develop.
However, it’s important to note that antibody formation is relatively rare with either product, especially when treatments are spaced appropriately and administered by experienced injectors.
Botox Safety
Botox, on the other hand has decades of data about its efficacy and safety under its belt. The additional proteins in Botox’s formulation contribute to its stability and predictable behavior, which translates to more consistent results from treatment to treatment.
Additionally, Botox tends to stay more precisely where it’s injected, making it ideal for detailed work in delicate areas like around the eyes or for creating subtle, natural-looking results. This localized effect allows for more precise corrections and reduces the risk of affecting unintended muscle groups.
Cost Considerations
The cost of neurotoxin treatments can vary significantly based on your location, the provider’s experience, and the number of units needed for your treatment. In general, Xeomin and Botox are priced similarly, though you may find slight variations between providers.
Most practices price these treatments per unit, with typical treatment areas requiring anywhere from 10-50 units depending on the size of the area and the strength of your muscles. During your consultation, your provider can give you a more specific estimate based on your individual needs.
Remember that while cost is certainly a factor to consider, the skill and experience of your injector is far more important than saving a few dollars. Both products are only as good as the person administering them.
Which Should You Choose?
While both Xeomin and Botox are effective treatments, understanding why many providers and practices choose to focus on one can help inform your decision. At DermaBlue, we’ve chosen to specialize in Botox for several compelling reasons that benefit our patients.
Why We Focus on Botox at DermaBlue:
Brand Recognition and Patient Comfort
Botox is the original and most well-known neurotoxin treatment. Many patients specifically ask for Botox by name, which creates immediate comfort and trust. This familiarity helps patients feel more confident about their treatment choice.
Proven Track Record
With over two decades of use in aesthetic medicine, Botox has the longest history of consistent, reliable results. This extensive track record gives both providers and patients confidence in the treatment outcomes.
Faster Results
Many patients appreciate that Botox often shows initial results within 1-2 days, compared to 3-4 days with other neurotoxins. When you’re excited to see your results, those extra days can feel significant.
While some providers offer multiple neurotoxin options, we’ve found that focusing our expertise on Botox allows us to deliver the most predictable, satisfying results for our patients. Our injectors have extensive experience with Botox’s unique characteristics, optimal dosing, and injection techniques, which means better outcomes for you.
The truth is, both are excellent choices. Many patients are happy with either option, and some even alternate between the two. Your DermaBlue provider can help you decide based on your specific concerns, medical history, and aesthetic goals during a free 30-minute consultation.
What to Expect During Treatment
Regardless of which product you choose, the treatment experience is very similar. Your appointment will begin with a consultation where your provider assesses your facial anatomy, discusses your goals, and explains the treatment process.
The actual injection process takes just a few minutes.
You’ll feel small pinpricks as the product is injected into the targeted muscles. Most patients find the discomfort minimal and don’t require any numbing cream, though this can be provided if you’re particularly sensitive.
After treatment, you can return to most normal activities immediately. You’ll be advised to avoid lying down for a few hours, skip the gym for the rest of the day, and avoid massaging the treated areas to ensure the product stays where it was placed.
Results begin appearing within a few days and continue improving for up to two weeks. You’ll likely be scheduled for a follow-up appointment to assess your results and make any necessary touch-ups.
Making Your Decision
The choice between Xeomin and Botox doesn’t have to be overwhelming. Both are safe, effective treatments that can help you achieve your goals. The most important factors are finding a qualified, experienced provider and having realistic expectations about your results.
If you’re curious whether Botox or Xeomin would be a better fit for you, come on in for a free 30-minute consultation, where our experienced injectors can help you decide on the right treatment.
During your consultation, don’t hesitate to ask our providers any questions, their recommendations for your specific concerns, and what kind of results you can expect. We will take the time to explain your options and help you feel confident in your choice.
Remember, these treatments are temporary, so if you try one and aren’t completely satisfied, you can always discuss alternatives for your next treatment.
Many patients find that their preferences evolve over time as they become more experienced with neurotoxin treatments.
Frequently Asked Questions
Both treatments are typically priced similarly per unit, usually ranging from $10-15 per unit depending on your location and provider. The total cost depends on how many units you need for your treatment area, which varies by individual. At DermaBlue, we provide transparent pricing during your free 30-minute consultation so you know exactly what to expect.
Both Botox and Xeomin typically last 3-4 months, though individual results can vary based on factors like your metabolism, muscle strength, and the treatment area. Some patients find their results last slightly longer or shorter depending on their body’s response to the treatment.
Absolutely! Since both treatments are temporary, you can try a different neurotoxin for your next appointment if you want to compare results. Many patients who switch find they prefer one over the other, though both are highly effective for most people.
The injection experience is virtually identical for both treatments. Both use the same ultra-fine needles and similar injection techniques. Most patients describe the sensation as a quick pinprick that’s over in seconds. Any discomfort is brief and very manageable.
Some practices offer multiple options to give patients choice, while others (like DermaBlue) choose to specialize in one product to develop deep expertise and ensure consistent results. By focusing exclusively on Botox, our injectors become true specialists in its unique characteristics, dosing, and optimal injection techniques – which often leads to better outcomes for patients.
